Genetics of mental retardation & cortical malformations

Our team

• About us...
• Composition
• Recent publications

Mental retardation

• Introduction
• Positional cloning
• Our work

Rett syndrome

• Introduction
• Clinical signs
• MeCP2 mutations
• Phenotypes
• Our work / Network

Cortical malformations

• Introduction
• Polymicrogyria
• Heterotopia
• Lissencephaly
• Classification
• Genetic causes
• Our work

Epilepsy

• The project
• Our work
• Call for collaboration

To read in august...

- Role of Olig1 and Olig2 in Down syndrome.

- TUBA1A mutations cause wide spectrum lissencephaly.

- Cell cloning-based transcriptome analysis in Rett patients.

About us

Our laboratory is located in "La Timone" Medical School in Marseilles, in a research unit of the French Institute for Health and Medical Research (INSERM) and of Aix-Marseille University.
Our research unit is called "Medical Genetics & Functional Genomics".

It is composed of 5 independent teams headed by :

Laurent Villard - Team 1 - Genetics of mental retardation and cortical malformations.

Nicolas Lévy - Team 2 - Genetics of neuromuscular disorders and laminopathies.

Michael Mitchell - Team 3 - Molecular genetics of spermatogenesis.

Stéphane Zaffran - Team 4 - Genetics, patterning and cardiac diseases.

Marc Jamon - Team 5 - Functional genomics, behaviours and pathologies.

Team 1 is funded by

INSERM

Aix-Marseille University (Université de la Méditerranée)

National Research Agency (Agence Nationale de la Recherche, ANR)

French Rett Syndrome Association (Association Française du Syndrome de Rett, AFSR)

Jérôme Lejeune Foundation

City of Marseille

ERA-Net for research programmes on rare diseases (E-RARE)

Marie Curie Initial Training Networks (ITN)

French Foundation for Research on Epilepsy (FFRE)

Clinical Research Program Funds (PHRC)

Provence-Alps-Côte d'Azur Regional Council