RETT syndrome

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our results and projects

The discovery that the MECP2 gene in causing Rett syndrome in more than 95% of the cases was a breakthrough. However, even though the molecular basis of the syndrome is now known, its pathophysiology remains mysterious.


The identification of the MECP2 gene lead to the creation of a mouse model in which the homologous Mecp2 gene was deleted (Guy et al., 2001). These mice reproduce most aspects of the human Rett syndrome phenotype. They are most useful tools to understand the condition and to analyze the different clinical manifestations in great detail.


The results that we have obtained in the group and our current projects are presented in the following pages.

> CatecholaminesRettcatechos_gb.html
> Motor functionRettmotrice_gb.html
> PharmacologyRettpharmaco_gb.html
> Gene therapyRetttherapie_gb.html
> European networksRettreseaux_gb.html