jean-christophe roux

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Inserm UMR-S 1251 - MMG

Faculté de Médecine de La Timone

27 Bd Jean Moulin

13385 Marseille cedex 5

France


Tél : +33 (0)4 91 32 49 04

Fax : +33 (0)4 91 80 43 19

E-mail : jean-christophe.roux (AT) univ-amu.fr

DIRECTEUR DE RECHERCHE a l’inserm

PUBLICATIONS


2021

Analysis of astroglial secretomic profile in the Mecp2-deficient male mouse model of Rett syndrome.
Ehinger Y, Matagne V, Cunin V, Borloz E, Sève M, Bourgoin-Voilard S, Borges-Correia A, Villard L, Roux JC.
International Journal of Molecular Sciences, 2021, in press.

Severe off-target effects following intravenous delivery of AAV9-MECP2 in a female mouse model of Rett syndrome.
Matagne V, Borloz E, Ehinger Y, Saidi L, Villard L, Roux JC.
Neurobiology of Disease, 2021, 149:105235.


2020

A knock-in mouse model for KCNQ2-related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment.
Milh M, Roubertoux P, Biba N, Chavany J, Spiga Ghata A, Fulachier C, Collins SC, Wagner C, Roux JC, Yalcin B, Félix MS, Molinari F, Lenck-Santini PP, Villard L.
Epilepsia, 2020, 61:868-878.

Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice.
Ehinger Y, Bruyere J, Panayotis N, Abada YS, Borloz E, Matagne V, Scaramuzzino C, Vitet H, Delatour B, Saidi L, Villard L, Saudou F, Roux JC.
EMBO Molecular Medicine, 2020, 12:e10889.


2018

Rett syndrome from bench to bedside: recent advances.
Ehinger Y, Matagne V, Villard L, Roux JC.
F1000 Research, 2018, 7:398-.


2017

Effect of desipramine on patients with breathing disorders in Rett syndrome.
Mancini J, Dubus JC, Jouve E, Roux JC, Lagrue E, Castelnau P, Cances C, Chaix Y, Rougeot Jung C, Desportes V, Franco P, Vallée L, Bahi-Buisson N, Truillet R, Villard L, Blin O, Micallef J.
Annals of Clinical and Translational Neurology, 2017, 27:118-127.

A codon optimized Mecp2 transgene corrects breathing deficits and improves survival in a mouse model of Rett syndrome.
Matagne V, Ehinger Y, Saidi L, Borges-Correia A, Barkats M, Bartoli M, Villard L, Roux JC.
Neurobiology of Disease, 2017, 99:1-11.


2014

GABA and glutamate pathways are spatially and developmentally affected in the brain of Mecp2-deficient mice.
El-Khoury R, Panayotis N, Matagne V, Ghata A, Villard L, Roux JC.
PLoS One, 2014, 9:e92169.


2013

Isoform-specific anti-MeCP2 antibodies confirm that expression of the e1 isoform strongly predominates in the brain.
Kaddoum L, Panayotis N, Mazarguil H, Giglia-Mari G, Roux JC, Joly E.
F1000Res. 2013, 2:204.

Mutations in BCAP31 cause a severe X-linked phenotype with deafness, dystonia, and central hypomyelination and disorganize the Golgi apparatus.
Cacciagli P, Sutera-Sardo J, Borges-Correia A, Roux JC, Dorboz I, Desvignes JP, Badens C, Delepine M, Lathrop M, Cau P, Lévy N, Girard N, Sarda P, Boespflug-Tanguy O, Villard L.
American Journal of Human Genetics, 2013, 93:579-586.

DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease.
Sanchez-Mut JV, Aso E, Panayotis N, Lott I, Dierssen M, Rabano A, Urdinguio RG, Fernandez AF, Astudillo A, Martin-Subero JI, Balint B, Fraga MF, Gomez A, Gurnot C, Roux JC, Avila J, Hensch TK, Ferrer I, Esteller M.
Brain, 2013, 136:3018-3027.


2012

Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway.
Roux JC, Zala D, Panayotis N, Borges-Correia A, Saudou F, Villard L.
Neurobiology of Disease, 2012, 45:786-795.


2011
 
Biogenic amines and their metabolites are differentially affected in the Mecp2-deficient mouse brain.
Panayotis N, Ghata A, Villard L, Roux JC.
BMC Neuroscience, 2011, 12:47.

Progressive motor and respiratory metabolism deficits in post-weaning Mecp2-null male mice.
Pratte M, Panayotis N, Ghata A, Villard L, Roux JC.
Behavioural Brain Research, 2011, 216:313-320.

Morphological and Functional Alterations in the Substantia Nigra pars compacta of the Mecp2-null mouse.
Panayotis N, Pratte M, Borges-Correia A, Ghata A, Villard L, Roux JC.
Neurobiology of Disease, 2011, 41:385-397.


2010

Biogenic amines in Rett syndrome : the usual suspects.
Roux JC, Villard L.
Behavior Genetics, 2010, 40:55-75.

Progressive noradregernic deficits in the locus coeruleus of the Mecp2 deficient mouse.
Roux JC, Panayotis N, Dura E, Villard L.
Journal of Neuroscience Research, 2010, 88:1500-1509.


2009

Spatiotemporal expression in mouse brain of Kiaa2022, a gene disrupted in two patients with severe mental retardation.
Cantagrel V, Haddad MR, Ciofi P, Andrieu D, Lossi AM, van Maldergem L, Roux JC, Villard L.
Gene Expression Patterns, 2009, 9:423-429.


2008

Expression of methyl-CpG binding protein 2 (Mecp2) during the postnatal development of the mouse brainstem.
Dura E, Villard L, Roux JC.
Brain Research, 2008, 1236:176-184.

Tyrosine hydroxylase deficit in the chemoafferent and the sympathoadrenergic pathways of the Mecp2 deficient mouse.
Roux JC, Dura E, Villard L.
Neuroscience Letters, 2008, 447:82-86.


2007

Pharmacological treatment of Rett syndrome improve breathing and survival in a mouse model.
Roux JC, Villard L.
Médecine & Sciences, 2007, 23:805-807.

Developmental plasticity of the carotid chemoafferent pathway in rats that are hypoxic during the prenatal period.
Peyronnet J, Roux JC, Mamet J, Perrin D, Lachuer J, Pequignot JM, Dalmaz Y.
European Journal of Neuroscience, 2007, 26:2865-2872.

Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome.
Roux JC, Dura E, Moncla A, Mancini J, Villard L.
European Journal of Neuroscience, 2007, 25:1915-1922.


2006

Noradrenaline deficiency as the origin of respiratory disorders in an animal model of Rett syndrome.
Villard L, Roux JC.
Médecine & Sciences, 2006, 22:81-83.

Possible modulation of the mouse respiratory rhythm generator by A1/C1 neurones.
Zanella S, Roux JC, Viemari JC, Hilaire G.
Respiratory Physiology and Neurobiology, 2006, 153:126-138.


2005

Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice : implications for Rett syndrome.
Roux JC, Viemari JC, Tryba AK, Saywell V, Burnet H, Pena F, Zanella S, Bévengut M, Barthélémy-Requin M, Herzing LB, Moncla A, Mancini J, Ramirez JM, Villard L, Hilaire G.
Journal of Neuroscience, 2005, 25:11521-11530.

Developmental changes in HIF transcription factor in carotid body: relevance for O2 sensing by chemoreceptors.
Roux JC, Brismar H, Aperia A, Lagercrantz H.
Pediatric Research, 2005, 58:53-57.

Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function.
Cohen G, Roux JC, Grailhe R, Malcolm G, Changeux JP, Lagercrantz H.
Proc Natl Acad Sci USA, 2005, 102:3817-3821.


2004

Chemosensory inputs and neural remodeling in carotid body and brainstem catecholaminergic cells.
Soulage C, Pascual O, Roux JC, Denavit-Saubie M, Pequignot JM.
Advances in Experimental Medicine and Biology, 2004, 551:53-58.

Long-term prenatal hypoxia alters maturation of brain catecholaminergic systems and motor behavior in rats.
Perrin D, Mamet J, Scarna H, Roux JC, Berod A, Dalmaz Y.
Synapse, 2004, 54:92-101.

Carotid chemodenervation approach to study oxygen sensing in brain stem catecholaminergic cells.
Pascual O, Roux JC, Soulage C, Morin-Surun MP, Denavit-Saubie M, Pequignot JM.
Methods in Enzymology, 2004, 381:422-449.

Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice.
Nsegbe E, Wallen-Mackenzie A, Dauger S, Roux JC, Shvarev Y, Lagercrantz H, Perlmann T, Herlenius E.
Journal of Physiology, 2004, 556:43-59.


2003

Prenatal hypoxia and early postnatal maturation of the chemoafferent pathway.
Peyronnet J, Roux JC, Perrin D, Pequignot JM, Lagercrantz H, Dalmaz Y.
Advances in Experimental Medicine and Biology, 2003, 536:525-533.

Neurochemical development of the brainstem catecholaminergic cell groups in rat.
Roux JC, Mamet J, Perrin D, Peyronnet J, Royer C, Cottet-Emard JM, Pequignot JM, Dalmaz Y.
Journal of Neural Transmission, 2003, 110:51-65.


2002

Long-lasting adverse effects of prenatal hypoxia on developing autonomic nervous system and cardiovascular parameters in rats.
Peyronnet J, Dalmaz Y, Ehrstrom M, Mamet J, Roux JC, Pequignot JM, Thoren HP, Lagercrantz H.
Pflugers Archives, 2002, 443:858-865.

Long-term prenatal hypoxia alters maturation of adrenal medulla in rat.
Mamet J, Peyronnet J, Roux JC, Perrin D, Cottet-Emard JM, Pequignot JM, Lagercrantz H, Dalmaz Y.
Pediatric Research, 2002, 51:207-214.


2000

O2-sensing after carotid chemodenervation: hypoxic ventilatory responsiveness and upregulation of tyrosine hydroxylase mRNA in brainstem catecholaminergic cells.
Roux JC, Pequignot JM, Dumas S, Pascual O, Ghilini G, Pequignot J, Mallet J, Denavit-Saubie M.
European Journal of Neuroscience, 2000, 12:3181-3190.

Neurochemical reorganization of O2 chemoreflex pathway after carotid body denervation in rats.
Roux JC, Peyronnet J, Pascual O, Dalmaz Y, Pequignot JM.
Advances in Experimental Medicine and Biology, 2000, 475:823-828.

Prenatal hypoxia impairs the postnatal development of neural and functional chemoafferent pathway in rat.
Peyronnet J, Roux JC, Geloen A, Tang LQ, Pequignot JM, Lagercrantz H, Dalmaz Y.
Journal of Physiology, 2000, 524:525-537.

Ventilatory and central neurochemical reorganisation of O2 chemoreflex after carotid sinus nerve transection in rat.
Roux JC, Peyronnet J, Pascual O, Dalmaz Y, Pequignot JM.
Journal of Physiology, 2000, 522:493-501.
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